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Article

Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria

30 Jun 2011

Abstract excerpt

Antibiotic resistance mechanisms reported in Gram-negative bacteria are causing a worldwide health problem. The continuous dissemination of 'multidrug-resistant' (MDR) bacteria drastically reduces the efficacy of our antibiotic 'arsenal' and consequently increases the frequency of therapeutic failure. In MDR bacteria, the overexpression of efflux pumps that expel structurally unrelated drugs contributes to the...

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PMID: 21707670
DOI: 10.1111/j.1574-6976.2011.00290.x

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