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The <i>Burkholderia pseudomallei</i> BpeAB-OprB Efflux Pump: Expression and Impact on Quorum Sensing and Virulence

1 Jul 2005

Abstract excerpt

BpeAB-OprB is a multidrug efflux pump of the bacterial pathogen Burkholderia pseudomallei and is responsible for conferring antimicrobial resistance to aminoglycosides and macrolides. Expression of bpeAB-oprB is inducible by its substrate erythromycin and upon entry into stationary phase. BpeR, a member of the TetR family, functions as a repressor of the bpeAB-oprB operon. bpeR expression was similarly induced at...

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PMID: 15995185
DOI: 10.1128/jb.187.14.4707-4719.2005

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