Article
In vitro activity of cethromycin against Burkholderia pseudomallei and investigation of mechanism of resistance.
The Journal of antimicrobial chemotherapy - 1 Jan 2011
Mima Takehiko, Schweizer Herbert P, Xu Ze-Qi
Abstract excerpt
OBJECTIVES: most Burkholderia pseudomallei strains are intrinsically resistant to macrolides, mainly due to AmrAB-OprA- and/or BpeAB-OprB-mediated efflux. We assessed the in vitro anti-B. pseudomallei efficacy of cethromycin, a novel ketolide with broad-spectrum activity against Gram-negative and Gram-positive pathogens. METHODS: the 2-fold broth microdilution technique was used to assess the in vitro cethromycin...
Topics
- Anti-Bacterial Agents
- Burkholderia pseudomallei
- DNA Mutational Analysis
- Drug Resistance, Bacterial
- Gene Deletion
- Gene Expression Regulation, Bacterial
- Genetic Complementation Test
- Humans
- Ketolides
- Membrane Transport Proteins