Article
T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.
Immunity - 23 Apr 2010
Raab Monika, Wang Hongyan, Lu Yuning, Smith Xin, Wu Zhonglin, Strebhardt Klaus, Ladbury John E, Rudd Christopher E
Abstract excerpt
Although essential for T cell function, the identity of the T cell receptor "inside-out" pathway for lymphocyte function-associated antigen 1 (LFA-1) adhesion has proved elusive. Here, we define the "inside-out" pathway mediated by N-terminal SKAP1 (SKAP-55) domain binding to the C-terminal SARAH domain of RapL. TcR induced Rap1-RapL complex formation and LFA-1 binding failed to occur in Skap1(-/-) primary T...
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