Article
Gp41 dynamically interacts with the TCR in the immune synapse and promotes early T cell activation.
Scientific reports - 27 Jun 2018
Yakovian Oren, Schwarzer Roland, Sajman Julia, Neve-Oz Yair, Razvag Yair, Herrmann Andreas, Sherman Eilon
Abstract excerpt
The HIV-1 glycoprotein gp41 critically mediates CD4+ T-cell infection by HIV-1 during viral entry, assembly, and release. Although multiple immune-regulatory activities of gp41 have been reported, the underlying mechanisms of these activities remain poorly understood. Here we employed multi-colour single molecule localization microscopy (SMLM) to resolve interactions of gp41 proteins with cellular proteins at the...
Topics
- Cell Line
- HIV Envelope Protein gp41
- Humans
- Lymphocyte Activation
- Mutation
- Receptors, Antigen, T-Cell
- Software
- Synapses
- T-Lymphocytes