Article
Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus.
Annals of the rheumatic diseases - 1 Nov 2010
Fürnrohr Barbara G, Wach Sven, Kelly Jennifer A, Haslbeck Martin, Weber Christian K, Stach Christian M, Hueber Axel J, Graef Daniela, Spriewald Bernd M, Manger Karin, Herrmann Martin, Kaufman Kenneth M, Frank Summer G, Goodmon Ellen, James Judith A, Schett Georg, Winkler Thomas H, Harley John B, Voll Reinhard E
Abstract excerpt
BACKGROUND: Heat shock proteins (Hsps) play a role in the delivery and presentation of antigenic peptides and are thought to be involved in the pathogenesis of multifactorial diseases. OBJECTIVE: To investigate genes encoding cytosolic Hsp70 proteins for associations of allelic variants with systemic lupus erythematosus (SLE). METHODS: Case-control studies of two independent Caucasian SLE cohorts were performed....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.