Article
The role of hsp90 in SLE.
Autoimmunity - 1 Jan 1994
Latchman D S, Isenberg D A
Abstract excerpt
The heat shock proteins are a group of evolutionarily conserved proteins with important physiological functions, whose synthesis is enhanced by elevated temperature or other stresses. A role for one or more of these proteins in human autoimmune disease has been extensively discussed. This review considers the evidence of a role for hsp90 in systemic lupus erythematosus (SLE) where overexpression of this protein,...
Topics
- Animals
- Autoantibodies
- Autoantigens
- Autoimmune Diseases
- Disease Models, Animal
- Disease Susceptibility
- Gene Expression Regulation
- Genetic Predisposition to Disease
- HLA-A1 Antigen
- HLA-B8 Antigen
- HLA-DR3 Antigen
- HSP90 Heat-Shock Proteins