Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular markers of systemic autoimmune disorders: the expression of MHC-located HSP70 genes is significantly associated with autoimmunity development.

Clinical and experimental rheumatology - 1 Jan 2000

Mišunová Martina, Svitálková Tana, Pleštilová Lenka, Kryštufková Olga, Tegzová Dana, Svobodová Radka, Hušáková Marketa, Tomčík Michal, Bečvář Radim, Závada Jakub, Mann Herman, Kolesár Libor, Slavčev Antonij, Vencovský Jiri, Novota Peter

Abstract excerpt

OBJECTIVES: To analyse the expression regulation of two inducible HSP70 genes - HSPA1A and HSPA1B - located within the major histocompatibility complex (MHC) in patients with various systemic autoimmune diseases and to prove the reliability of MHC-located HSP70 genes as molecular markers reflecting the autoimmune process. METHODS: 94 adult patients with idiopathic inflammatory myopathy (IIM, n=31), systemic lupus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers

Share to Gene Expression Regulation

Share to HSP70 Heat-Shock Proteins

Share to Lupus Erythematosus, Systemic

Share to Myositis

Share to Scleroderma, Systemic

Source

Identifiers

PMID: 28032847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular markers of systemic autoimmune disorders: the expression of MHC-located HSP70 genes is significantly associated with autoimmunity development.PMID 28032847Read ↗

Dual role of autoantibodies to heat shock proteins in autoimmune diseasesSemantic proximity Read ↗

HSP70-1 promoter region polymorphism tested in three autoimmune diseases.Semantic proximity Read ↗

Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus.Semantic proximity Read ↗

A major genetic determinant of autoimmune diseases is associated with the presence of autoantibodies in hypersensitivity pneumonitis.Semantic proximity Read ↗

The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertensionSemantic proximity Read ↗

Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis.Semantic proximity Read ↗

The role of hsp90 in SLE.Semantic proximity Read ↗

Molecular analysis of HLA-DPB1 alleles in idiopathic systemic sclerosis patients and uranium miners with systemic sclerosis.Semantic proximity Read ↗

Are Hsp70 protein expression and genetic polymorphism implicated in multiple sclerosis inflammation?Semantic proximity Read ↗

Association of human leukocyte antigen class II genes with autoantibody profiles, but not with disease susceptibility in Japanese patients with systemic sclerosis.Semantic proximity Read ↗

A novel variant of the MHC-linked hsp70, hsp70-hom, is associated with rheumatoid arthritis.Semantic proximity Read ↗

"2-6-11" motif in heat shock protein 60 and central nervous system antigens: a preliminary study in multiple sclerosis patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.