Article
HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility.
Cell stress & chaperones - 1 Sept 2010
Ucisik-Akkaya Esma, Davis Charronne F, Gorodezky Clara, Alaez Carmen, Dorak M Tevfik
Abstract excerpt
Three heat shock protein 70 (HSP70) genes, HSPA1L, HSPA1A, and HSPA1B, are located within the human leukocyte antigen (HLA) class III region. HSPs act as stress signals and regulate natural killer cell response to cancer. HSP70 gene polymorphisms show disease associations partly due to their linkage disequilibrium with HLA alleles. To systematically evaluate their associations with childhood acute lymphoblastic...
Topics
- Adolescent
- Adult
- Female
- Genetic Predisposition to Disease
- Genotype
- HSP70 Heat-Shock Proteins
- Haplotypes
- Humans
- Male
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single Nucleotide
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Sex Factors