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Article

Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion.

Science signaling - 7 Jan 2020

Lee Seongju, Park Hyungsun, Zhu Peng-Peng, Jung Soon-Young, Blackstone Craig, Chang Jaerak

Abstract excerpt

Mutations in WASHC5 (also known as KIAA0196) cause autosomal dominant hereditary spastic paraplegia (HSP) type SPG8. WASHC5, commonly called strumpellin, is a core component of the Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex that activates actin nucleation at endosomes. Although various other cellular roles for strumpellin have also been described, none account for how SPG8-associated...

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Source

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Identifiers

PMID: 31911435
DOI: 10.1126/scisignal.aau7500
PMCID: PMC7231525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion.PMID 31911435Read ↗

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