Article
Both BRAF and KRAS mutations are rare in colorectal carcinomas from patients with hereditary nonpolyposis colorectal cancer.
Cancer letters - 28 Jul 2004
Miyaki Michiko, Iijima Takeru, Yamaguchi Tatsuro, Kadofuku Tsuyoki, Funata Nobuaki, Mori Takeo
Abstract excerpt
The BRAF mutations have been suggested to be linked with defective mismatch repair in colorectal carcinomas. To clarify the extent of BRAF mutations in HNPCC colorectal carcinomas, which are typical mismatch repair deficient carcinomas, we compared the frequency of BRAF mutations between HNPCC, familial adenomatous polyposis (FAP) and sporadic cases. The frequency of KRAS mutations was also compared between these...
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