Article
Parkin suppresses c-Jun N-terminal kinase-induced cell death via transcriptional regulation in Drosophila.
Molecules and cells - 1 Jun 2010
Hwang Soojin, Kim Darae, Choi Gahee, An Seon Woo, Hong Yoon Ki, Suh Yoon Seak, Lee Min Jung, Cho Kyoung Sang
Abstract excerpt
Parkin is the most prevalent genetic factor in the onset of autosomal recessive juvenile parkinsonism (AR-JP), and mutations in parkin has been reported to cause motor defects, which result from dopamine deficiency caused by dopaminergic neuronal cell death. Activation of c-Jun N-terminal kinase (JNK) has also been implicated in neuronal cell death in Parkinson's disease (PD). Moreover, Drosophila models for...
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