Infrequent p53 gene alterations in ulcerative colitis.

doi:10.1590/s0100-879x1999000900005

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Article

Infrequent p53 gene alterations in ulcerative colitis.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Sept 1999

Mattar R, Alexandrino A M, Laudanna A A

Abstract excerpt

The purpose of this study was to determine whether point mutations and loss of the p53 gene take place in ulcerative colitis which is histologically negative for dysplasia. DNA was extracted from 13 frozen rectal or colon biopsies and blood samples. Ulcerative colitis was classified histologically as active (10 cases) and inactive (3 cases). Exons 5-8 were amplified by PCR, treated with exonuclease and shrimp...

Topics

Adult
Biomarkers
Colitis, Ulcerative
Female
Genes, p53
Humans
Male
Middle Aged
Mutation
Polymerase Chain Reaction
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 10464383
DOI: 10.1590/s0100-879x1999000900005

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