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Article

Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas.

Oncology reports - 1 Jan 2000

Pereira P, Stanton V, Jothy S, Tomlinson I P, Foulkes W D, Rozen R

Abstract excerpt

Folate derivatives are essential for DNA synthesis and methylation. A large proportion of the Caucasian population is heterozygous for a common substitution, 677C-->T (alanine-->valine), in methylenetetrahydrofolate reductase (MTHFR), an enzyme of folate interconversion. Homozygous mutant individuals, approximately 10-15% of North Americans, have been reported to have a reduced risk of colorectal cancer. We...

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Source

Identifiers

PMID: 10203598
DOI: 10.3892/or.6.3.597

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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