Article

Integration of multidimensional splicing data and GWAS summary statistics for risk gene discovery

2021-09-15

Abstract excerpt

A common strategy for the functional interpretation of genome-wide association study (GWAS) findings has been the integrative analysis of GWAS and expression data. Using this strategy, many association methods (e.g., PrediXcan and FUSION) have been successful in identifying trait-associated genes via mediating effects on RNA expression. However, these approaches often ignore the effects of splicing, which carries...

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Literature Corpus work: 368e39ba-439d-537d-b1ed-7200f1c423a4
DOI: 10.1101/2021.09.13.460009

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