Integration of multidimensional splicing data and GWAS summary statistics for risk gene discovery.

Abstract excerpt

A common strategy for the functional interpretation of genome-wide association study (GWAS) findings has been the integrative analysis of GWAS and expression data. Using this strategy, many association methods (e.g., PrediXcan and FUSION) have been successful in identifying trait-associated genes via mediating effects on RNA expression. However, these approaches often ignore the effects of splicing, which can...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genome-Wide Association Study
• Share to Phenotype
• Share to Polymorphism, Single Nucleotide