Article
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.
The EMBO journal - 15 Jul 2003
Yan Catherine, Martinez-Quiles Narcisa, Eden Sharon, Shibata Tomoyuki, Takeshima Fuminao, Shinkura Reiko, Fujiwara Yuko, Bronson Roderick, Snapper Scott B, Kirschner Marc W, Geha Raif, Rosen Fred S, Alt Frederick W
Abstract excerpt
The Wiskott-Aldrich syndrome related protein WAVE2 is implicated in the regulation of actin-cytoskeletal reorganization downstream of the small Rho GTPase, Rac. We inactivated the WAVE2 gene by gene-targeted mutation to examine its role in murine development and in actin assembly. WAVE2-deficient embryos survived until approximately embryonic day 12.5 and displayed growth retardation and certain morphological...
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