Article
Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum.
Development (Cambridge, England) - 1 Aug 2001
Yamasaki T, Kawaji K, Ono K, Bito H, Hirano T, Osumi N, Kengaku M
Abstract excerpt
The molecular mechanisms that govern the coordinated programs of axonogenesis and cell body migration of the cerebellar granule cell are not well understood. In Pax6 mutant rats (rSey2/rSey2), granule cells in the external germinal layer (EGL) fail to form parallel fiber axons and to migrate tangentially along these fibers despite normal expression of differentiation markers. In culture, mutant cells sprout...
Topics
- Animals
- Axons
- Cell Differentiation
- Cell Division
- Cell Movement
- Cells, Cultured
- Central Nervous System
- Cerebellum
- Coculture Techniques
- Cytoskeleton
- DNA, Complementary
- Eye Proteins
- GTP Phosphohydrolases
- Homeodomain Proteins