Article
Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis.
PloS one - 1 Jan 2015
Ortiz Miguel A, Núñez Concepción, Ordóñez David, Alvarez-Cermeño José C, Martínez-Rodriguez José E, Sánchez Antonio J, Arroyo Rafael, Izquierdo Guillermo, Malhotra Sunny, Montalban Xavier, García-Merino Antonio, Munteis Elvira, Alcina Antonio, Comabella Manuel, Matesanz Fuencisla, Villar Luisa M, Urcelay Elena
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Histocompatibility Complex. Additional risk loci with immunologically relevant genes were found...
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