Article
Iron-sulfur-protein biogenesis in eukaryotes.
Trends in biochemical sciences - 1 Mar 2005
Lill Roland, Mühlenhoff Ulrich
Abstract excerpt
Iron-sulfur (Fe-S) clusters (ISCs) are versatile, ancient co-factors of proteins that are involved in electron transport, enzyme catalysis and regulation of gene expression. The synthesis of ISCs and their insertion into apoproteins involves the function of complex cellular machineries. In eukaryotes, the mitochondrial ISC-assembly machinery is involved in the maturation of all cellular iron-sulfur proteins. A...
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