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Mitochondrial iron-sulfur cluster biogenesis and neurological disorders.

Mitochondrion - 1 Jan 2022

Selvanathan Arthavan, Parayil Sankaran Bindu

Abstract excerpt

Iron-sulfur clusters (ISCs) are highly conserved moieties embedded into numerous crucial proteins in almost all bacteria, plants and mammals. As such, ISC biosynthesis is critical to cellular function. The pathway was first characterized in bacteria by the late 1990s, and over the subsequent 20 years there has been increasing understanding of its components in humans. Defects in the ISC pathway are now associated...

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PMID: 34687937
DOI: 10.1016/j.mito.2021.10.004

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