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Article

Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues.

Human molecular genetics - 15 Nov 2007

Martelli Alain, Wattenhofer-Donzé Marie, Schmucker Stéphane, Bouvet Samuel, Reutenauer Laurence, Puccio Hélène

Abstract excerpt

Friedreich ataxia, the most common recessive ataxia, is caused by the deficiency of the mitochondrial protein frataxin (Fxn), an iron chaperone involved in the assembly of Fe-S clusters (ISC). In yeast, mitochondria play a central role for all Fe-S proteins, independently of their subcellular localization. In mammalian cells, this central role of mitochondria remains controversial as an independent cytosolic ISC...

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PMID: 17597094
DOI: 10.1093/hmg/ddm163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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