Article
Mammalian Fe-S cluster biogenesis and its implication in disease.
Biochimie - 1 May 2014
Beilschmidt Lena K, Puccio Hélène M
Abstract excerpt
Iron-sulfur (Fe-S) clusters are inorganic cofactors that are ubiquitous and essential. Due to their chemical versatility, Fe-S clusters are implicated in a wide range of protein functions including mitochondrial respiration and DNA repair. Composed of iron and sulfur, they are sensible to oxygen and their biogenesis requires a highly conserved protein machinery that facilitates assembly of the cluster as well as...
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