Article
Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Mar 2010
Zarghooni Maryam, Bartels Ute, Lee Eric, Buczkowicz Pawel, Morrison Andrew, Huang Annie, Bouffet Eric, Hawkins Cynthia
Abstract excerpt
PURPOSE: Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating of pediatric malignancies and one for which no effective therapy exists. A major contributor to the failure of therapeutic trials is the assumption that biologic properties of brainstem tumors in children are identica...
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