PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma.

doi:10.1111/bpa.12043

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Article

PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma.

Brain pathology (Zurich, Switzerland) - 1 Sept 2013

Phillips Joanna J, Aranda Derick, Ellison David W, Judkins Alexander R, Croul Sidney E, Brat Daniel J, Ligon Keith L, Horbinski Craig, Venneti Sriram, Zadeh Gelareh, Santi Mariarita, Zhou Shengmei, Appin Christina L, Sioletic Stefano, Sullivan Lisa M, Martinez-Lage Maria, Robinson Aaron E, Yong William H, Cloughesy Timothy, Lai Albert, Phillips Heidi S, Marshall Roxanne, Mueller Sabine, Haas-Kogan Daphne A, Molinaro Annette M, Perry Arie

Abstract excerpt

High-grade astrocytomas (HGAs), corresponding to World Health Organization grades III (anaplastic astrocytoma) and IV (glioblastoma; GBM), are biologically aggressive, and their molecular classification is increasingly relevant to clinical management. PDGFRA amplification is common in HGAs, although its prognostic significance remains unclear. Using fluorescence in situ hybridization (FISH), the most sensitive...

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PMID: 23438035
DOI: 10.1111/bpa.12043
PMCID: PMC3715570

Genes

PDGFRA
IDH1

Variants

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