Article
Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Oct 2011
Paugh Barbara S, Broniscer Alberto, Qu Chunxu, Miller Claudia P, Zhang Junyuan, Tatevossian Ruth G, Olson James M, Geyer J Russell, Chi Susan N, da Silva Nasjla Saba, Onar-Thomas Arzu, Baker Justin N, Gajjar Amar, Ellison David W, Baker Suzanne J
Abstract excerpt
PURPOSE: Long-term survival for children with diffuse intrinsic pontine glioma (DIPG) is less than 10%, and new therapeutic targets are urgently required. We evaluated a large cohort of DIPGs to identify recurrent genomic abnormalities and gene expression signatures underlying DIPG. PATIENTS AND METHODS: Single-nucleotide polymorphism arrays were used to compare the frequencies of genomic copy number...
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