Article
Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma.
Oncotarget - 4 Oct 2016
Koschmann Carl, Zamler Daniel, MacKay Alan, Robinson Dan, Wu Yi-Mi, Doherty Robert, Marini Bernard, Tran Dustin, Garton Hugh, Muraszko Karin, Robertson Patricia, Leonard Marcia, Zhao Lili, Bixby Dale, Peterson Luke, Camelo-Piragua Sandra, Jones Chris, Mody Rajen, Lowenstein Pedro R, Castro Maria G
Abstract excerpt
Pediatric high-grade glioma (HGG, WHO Grade III and IV) is a devastating brain tumor with a median survival of less than two years. PDGFRA is frequently mutated/ amplified in pediatric HGG, but the significance of this finding has not been fully characterized. We hypothesize that alterations of PDGFRA will promote distinct prognostic and treatment implications in pediatric HGG. In order to characterize the impact...
Topics
- Adolescent
- Adult
- Age Factors
- Antineoplastic Agents
- Apoptosis
- Biomarkers, Tumor
- Brain Neoplasms
- Cell Proliferation
- Child
- Child, Preschool