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Article

Pathology, Molecular Genetics, and Epigenetics of Diffuse Intrinsic Pontine Glioma

30 Jun 2015

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric brain cancer with no effective therapy. Histological similarity of DIPG to supratentorial high-grade astrocytomas of adults has led to assumptions that these entities possess similar underlying molecular properties and therefore similar therapeutic responses to standard therapies. The failure of all clinical trials in the last 30 years to improve...

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PMID: 26175967
DOI: 10.3389/fonc.2015.00147

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