Article
Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.
PloS one - 1 Jan 2012
Puget Stephanie, Philippe Cathy, Bax Dorine A, Job Bastien, Varlet Pascale, Junier Marie-Pierre, Andreiuolo Felipe, Carvalho Dina, Reis Ricardo, Guerrini-Rousseau Lea, Roujeau Thomas, Dessen Philippe, Richon Catherine, Lazar Vladimir, Le Teuff Gwenael, Sainte-Rose Christian, Geoerger Birgit, Vassal Gilles, Jones Chris, Grill Jacques
Abstract excerpt
Diffuse intrinsic pontine glioma (DIPG) is one of the most frequent malignant pediatric brain tumor and its prognosis is universaly fatal. No significant improvement has been made in last thirty years over the standard treatment with radiotherapy. To address the paucity of understanding of DIPGs, we have carried out integrated molecular profiling of a large series of samples obtained with stereotactic biopsy at...
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