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Article

Haploinsufficiency of mTR results in defects in telomere elongation.

Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002

Hathcock Karen S, Hemann Michael T, Opperman Kay Keyer, Strong Margaret A, Greider Carol W, Hodes Richard J

Abstract excerpt

Telomeres are usually maintained about an equilibrium length, and the set point for this equilibrium differs between species and between strains of a given species. To examine the requirement for telomerase in mediating establishment of a new telomere length equilibrium, we generated interspecies...

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Identifiers

PMID: 11904421
DOI: 10.1073/pnas.012549799
PMCID: PMC122568

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11904421-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Haploinsufficiency of mTR results in defects in telomere elongation.PMID 11904421Read ↗

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Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.Semantic proximity Read ↗

Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes.Semantic proximity Read ↗

Telomere length is an epigenetic trait - Implications for the use of telomerase-deficient organisms to model human disease.Semantic proximity Read ↗

Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice.Semantic proximity Read ↗

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.Semantic proximity Read ↗

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human lengthSemantic proximity Read ↗

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A possible role for telomerase RNA and telomere length in global mitotic recombination.Semantic proximity Read ↗

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