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Article

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

EMBO reports - 1 Sept 2001

Samper E, Flores J M, Blasco M A

Abstract excerpt

Reconstitution of telomerase activity is proposed as a potential gene therapy to prevent, or rescue, age-related diseases produced by critical telomere shortening. However, it is not known whether or not short telomeres are irreversibly damaged. We addressed this by re-introducing telomerase in late generation telomerase-deficient mice, Terc-/-, which have short telomeres and show severe proliferative defects....

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Identifiers

PMID: 11520856
DOI: 10.1093/embo-reports/kve174
PMCID: PMC1084029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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