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Article

Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants.

PLoS genetics - 1 Jul 2009

Chen Changchun, Tuck Simon, Byström Anders S

Abstract excerpt

Elongator is a six subunit protein complex, conserved from yeast to humans. Mutations in the human Elongator homologue, hELP1, are associated with the neurological disease familial dysautonomia. However, how Elongator functions in metazoans, and how the human mutations affect neural functions is incompletely understood. Here we show that in Caenorhabditis elegans, ELPC-1 and ELPC-3, components of the Elongator...

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Identifiers

PMID: 19593383
DOI: 10.1371/journal.pgen.1000561
PMCID: PMC2702823

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