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Article

Specific killing of Rb mutant cancer cells by inactivating TSC2.

Cancer cell - 18 May 2010

Li Binghui, Gordon Gabriel M, Du Charles H, Xu Jinhua, Du Wei

Abstract excerpt

The retinoblastoma (Rb) tumor suppressor is often inactivated in cancers. To identify genes that can be used to specifically target such cancers, we carried out a genetic screen in Drosophila. We identified gig (fly TSC2) and found that inactivation of rbf (fly Rb) and gig synergistically induced cell death. Interestingly, inactivation of TSC2 specifically kills Rb mutant cancer cells under stress conditions,...

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Source

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Identifiers

PMID: 20478529
DOI: 10.1016/j.ccr.2010.03.019
PMCID: PMC2873973

Genes

TSC2
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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