Article
Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene.
Genetics - 1 May 2005
Edgar Kyle A, Belvin Marcia, Parks Annette L, Whittaker Kellie, Mahoney Matt B, Nicoll Monique, Park Christopher C, Winter Christopher G, Chen Feng, Lickteig Kim, Ahmad Ferhad, Esengil Hanife, Lorenzi Matthew V, Norton Amanda, Rupnow Brent A, Shayesteh Laleh, Tabios Mariano, Young Lynn M, Carroll Pamela M, Kopczynski Casey, Plowman Gregory D, Friedman Lori S, Francis-Lang Helen L
Abstract excerpt
Mutations that inactivate the retinoblastoma (Rb) pathway are common in human tumors. Such mutations promote tumor growth by deregulating the G1 cell cycle checkpoint. However, uncontrolled cell cycle progression can also produce new liabilities for cell survival. To uncover such liabilities in Rb mutant cells, we performed a clonal screen in the Drosophila eye to identify second-site mutations that eliminate...
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