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Article

Generation of a conditional disruption of the <i>Tsc2</i> gene

24 Jan 2007

Abstract excerpt

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in the TSC1 or TSC2 gene. Patients afflicted with TSC develop tumors in various organ systems, but cerebral pathology is particularly severe. Conventional gene disruption of the Tsc1 or Tsc2 gene in mice cause limited central nervous system pathology. Homozygous deletion of either gene causes midgestation lethality. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17245776
DOI: 10.1002/dvg.20271

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Generation of a conditional disruption of the <i>Tsc2</i> genePMID 17245776Read ↗

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