Article

Tissue-Restricted Inhibition of mTOR Using Chemical Genetics

2022-03-09

Abstract excerpt

mTOR is a highly conserved eukaryotic protein kinase that coordinates cell growth and metabolism and plays a critical role in cancer, immunity, and aging. It remains unclear how mTOR signaling in individual tissues contributes to whole-organism processes because mTOR inhibitors, like the natural product Rapamycin, are administered systemically and target multiple tissues simultaneously. We developed a chemical-gen...

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Literature Corpus work: 0c66cdb6-9766-5cf5-923a-1c7026f0d190
DOI: 10.1101/2022.03.08.483534

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