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Article

Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila.

FEBS letters - 4 Aug 2010

Tsuda Manabu, Ootaka Ryousuke, Ohkura Chiaki, Kishita Yoshihito, Seong Ki-Hyeon, Matsuo Takashi, Aigaki Toshiro

Abstract excerpt

Overexpression of thioredoxin (TRX) confers oxidative stress resistance and extends lifespan in mammals and insects. However, less is known about phenotypes associated with loss of TRX. We investigated loss-of-function phenotypes of Trx-2 in Drosophila, and found that the mutant flies are hyper-susceptible to paraquat, a free radical generator, but not to hydrogen peroxide. They contain a high amount of protein...

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Identifiers

PMID: 20600005
DOI: 10.1016/j.febslet.2010.06.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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