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Article

Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase.

Nature - 15 Feb 2007

Hsu Ya-Chieh, Chern Joshua J, Cai Yi, Liu Mingyao, Choi Kwang-Wook

Abstract excerpt

Cellular growth and proliferation are coordinated during organogenesis. Misregulation of these processes leads to pathological conditions such as cancer. Tuberous sclerosis (TSC) is a benign tumour syndrome caused by mutations in either TSC1 or TSC2 tumour suppressor genes. Studies in Drosophila...

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Source

Identifiers

PMID: 17301792
DOI: 10.1038/nature05528

Genes

TSC2
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17301792-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase.PMID 17301792Read ↗

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.Semantic proximity Read ↗

Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival.Semantic proximity Read ↗

A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.Semantic proximity Read ↗

Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.Semantic proximity Read ↗

Regulation of cellular growth by the Drosophila target of rapamycin dTOR.Semantic proximity Read ↗

Drosophila Rheb GTPase is required for cell cycle progression and cell growth.Semantic proximity Read ↗

Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase.Semantic proximity Read ↗

The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.Semantic proximity Read ↗

Structural insights into TSC complex assembly and GAP activity on RhebSemantic proximity Read ↗

The dual role of the TSC complex in cancer.Semantic proximity Read ↗

The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction.Semantic proximity Read ↗

Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.Semantic proximity Read ↗

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