Autocrine activation of the IFN signaling pathway may promote immune escape in glioblastoma

Abstract excerpt

BACKGROUND: Interferons (IFNs) are cytokines typically induced upon viral infection but are constitutively expressed also in the absence of acute infection. The physiological role of autocrine and paracrine IFN signaling, however, remains poorly understood, and its function in glioblastoma has not been explored in depth. METHODS: Using RNA interference-mediated gene silencing, we characterized constitutive type I...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chemokine receptors and signaling
• Share to Cytokine Signaling Pathways and Interactions
• Share to interferon and immune responses