Article
DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.
Molecular cell - 14 May 2010
Schlereth Katharina, Beinoraviciute-Kellner Rasa, Zeitlinger Marie K, Bretz Anne C, Sauer Markus, Charles Joël P, Vogiatzi Fotini, Leich Ellen, Samans Birgit, Eilers Martin, Kisker Caroline, Rosenwald Andreas, Stiewe Thorsten
Abstract excerpt
p53 limits the proliferation of precancerous cells by inducing cell-cycle arrest or apoptosis. How the decision between survival and death is made at the level of p53 binding to target promoters remains unclear. Using cancer cell lines, we show that the cooperative nature of DNA binding extends the binding spectrum of p53 to degenerate response elements in proapoptotic genes. Mutational inactivation of...
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