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Article

Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2).

The Journal of biological chemistry - 27 Oct 2006

Tidow Henning, Veprintsev Dmitry B, Freund Stefan M V, Fersht Alan R

Abstract excerpt

The tumor suppressor p53 is frequently mutated in human cancers. Upon activation it can induce cell cycle arrest or apoptosis. ASPP2 can specifically stimulate the apoptotic function of p53 but not cell cycle arrest, but the mechanism of enhancing the activation of pro-apoptotic genes over cell cycle arrest genes remains unknown. In this study, we analyzed the binding of 53BP2 (p53-binding protein 2, the...

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Identifiers

PMID: 16887812
DOI: 10.1074/jbc.M604725200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2).PMID 16887812Read ↗

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