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Article

Abrogation of the transactivation activity of p53 by BCCIP down-regulation.

The Journal of biological chemistry - 19 Jan 2007

Meng Xiangbing, Yue Jingyin, Liu Zhihe, Shen Zhiyuan

Abstract excerpt

The tumor suppression function of p53 is mostly conferred by its transactivation activity, which is inactivated by p53 mutations in approximately 50% of human cancers. In cancers harboring wild type p53, the p53 transactivation activity may be compromised by other mechanisms. Identifying the mech...

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Source

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Identifiers

PMID: 17135243
DOI: 10.1074/jbc.M607520200
PMCID: PMC2679999

Genes

BCCIP
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17135243-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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