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Article

p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo.

Cell reports - 30 May 2013

Timofeev Oleg, Schlereth Katharina, Wanzel Michael, Braun Attila, Nieswandt Bernhard, Pagenstecher Axel, Rosenwald Andreas, Elsässer Hans-Peter, Stiewe Thorsten

Abstract excerpt

Four molecules of the tumor suppressor p53 assemble to cooperatively bind proapoptotic target genes. The structural basis for cooperativity consists of interactions between adjacent DNA binding domains. Mutations at the interaction interface that compromise cooperativity were identified in cancer...

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Identifiers

PMID: 23665223
DOI: 10.1016/j.celrep.2013.04.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23665223-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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