Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Directed evolution of p53 variants with altered DNA-binding specificities by in vitro compartmentalization.

Journal of molecular biology - 31 Aug 2007

Fen Chen Xue, Coomber David W, Lane David P, Ghadessy Farid J

Abstract excerpt

The p53 tumour suppressor governs cell fate by differential transactivation of a spectrum of target genes. To further understand how p53 discriminates between target promoters, we have for the first time used in vitro compartmentalization (IVC) to evolve variants with greater affinity for the dis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Line, Tumor
Share to Cell Separation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Evolution, Molecular

Share to Genes, p53

Share to Genetic Techniques

Share to Transcriptional Activation

Source

Identifiers

PMID: 17610896
DOI: 10.1016/j.jmb.2007.05.099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17610896-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Directed evolution of p53 variants with altered DNA-binding specificities by in vitro compartmentalization.PMID 17610896Read ↗

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay.Semantic proximity Read ↗

Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity.Semantic proximity Read ↗

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stabilitySemantic proximity Read ↗

Redefining the p53 response element.Semantic proximity Read ↗

DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.Semantic proximity Read ↗

Tumour p53 mutations exhibit promoter selective dominance over wild type p53.Semantic proximity Read ↗

Cell-free selection of RNA-binding proteins using in vitro compartmentalization.Semantic proximity Read ↗

Directed evolution of streptavidin variants using in vitro compartmentalization.Semantic proximity Read ↗

Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.Semantic proximity Read ↗

Low-level p53 expression changes transactivation rules and reveals superactivating sequencesSemantic proximity Read ↗

Direct selection of trans-acting ligase ribozymes by in vitro compartmentalization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.