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Article

p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis

18 Oct 2016

Abstract excerpt

Mutations in the oligomerization domain of p53 are genetically linked to cancer susceptibility in Li-Fraumeni Syndrome. These mutations typically alter the oligomeric state of p53 and impair its transcriptional activity. Activation of p53 through tetramerization is required for its tumor suppressive function by inducing transcriptional programs that lead to cell fate decisions such as cell cycle arrest or...

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PMID: 27754743
DOI: 10.1080/15384101.2016.1241917

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