Article
Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population.
PloS one - 1 Jan 2022
Beecham Ashley H, Amezcua Lilyana, Chinea Angel, Manrique Clara P, Gomez Lissette, Martinez Andrea, Beecham Gary W, Patsopoulos Nikolaos A, Chitnis Tanuja, Weiner Howard L, De Jager Philip L, Burchard Esteban G, Lund Brett T, Fitzgerald Kathryn C, Calabresi Peter A, Delgado Silvia R, Oksenberg Jorge R, McCauley Jacob L
Abstract excerpt
The Major Histocompatibility Complex (MHC) makes the largest genetic contribution to multiple sclerosis (MS) susceptibility, with 32 independent effects across the region explaining 20% of the heritability in European populations. Variation is high across populations with allele frequency differences and population-specific risk alleles identified. We sought to identify MHC-specific MS susceptibility variants and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.