Article
Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans.
Scientific reports - 9 Oct 2020
Nakatsuka Nathan, Patterson Nick, Patsopoulos Nikolaos A, Altemose Nicolas, Tandon Arti, Beecham Ashley H, McCauley Jacob L, Isobe Noriko, Hauser Stephen, De Jager Philip L, Hafler David A, Oksenberg Jorge R, Reich David
Abstract excerpt
Epidemiological studies have suggested differences in the rate of multiple sclerosis (MS) in individuals of European ancestry compared to African ancestry, motivating genetic scans to identify variants that could contribute to such patterns. In a whole-genome scan in 899 African-American cases and 1155 African-American controls, we confirm that African-Americans who inherit segments of the genome of European...
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