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Article

Host genetics in granuloma formation: human-like lung pathology in mice with reciprocal genetic susceptibility to M. tuberculosis and M. avium.

PloS one - 6 May 2010

Kondratieva Elena, Logunova Nadya, Majorov Konstantin, Averbakh Mikhail, Apt Alexander

Abstract excerpt

Development of lung granulomata is a hallmark of infections caused by virulent mycobacteria, reflecting both protective host response that restricts infection spreading and inflammatory pathology. The role of host genetics in granuloma formation is not well defined. Earlier we have shown that mice of the I/St strain are extremely susceptible to Mycobacterium tuberculosis but resistant to M. avium infection,...

Read the complete abstract on PubMed

Topics

Animals
Chemokines
Gene Expression Regulation
Genetic Predisposition to Disease
Granuloma
Host-Pathogen Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunity, Innate

Inflammation

Leukocyte Count

Lung

Mice

Mice, Inbred C57BL

Mycobacterium avium

Mycobacterium tuberculosis

Neutrophils

Phenotype

Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 20463893
DOI: 10.1371/journal.pone.0010515
PMCID: PMC2865535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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