Article
Neutrophil responses to Mycobacterium tuberculosis infection in genetically susceptible and resistant mice.
Infection and immunity - 1 Mar 2005
Eruslanov Evgenyi B, Lyadova Irina V, Kondratieva Tatiana K, Majorov Konstantin B, Scheglov Ilya V, Orlova Marianna O, Apt Alexander S
Abstract excerpt
The role of neutrophils in tuberculosis (TB) resistance and pathology is poorly understood. Neutrophil reactions are meant to target the offending pathogen but may lead to destruction of the host lung tissue, making the defending cells an enemy. Here, we show that mice of the I/St strain which are genetically susceptible to TB show an unusually high and prolonged neutrophil accumulation in their lungs after...
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