Article
Cellular and genetic mechanisms underlying susceptibility of animal models to tuberculosis infection.
Novartis Foundation symposium - 1 Jan 1998
Orme I
Abstract excerpt
I shall propose a new working hypothesis regarding the immunopathogenesis of tuberculosis infections in the mouse and guinea-pig models of pulmonary disease which differs from the current dogma that the development of caseous and potentially liquefied lesions in the susceptible guinea-pig lung is due to excessive expression of delayed-type hypersensitivity. I intend to show that the mouse is resistant because T...
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